Perturbation-first validation should precede therapeutic claims for DPP6 GWAS Signal: Cell-Type Regulatory Networks for PD Cognitive Decline

graph TD
    DPP6["DPP6"] -->|risk factor for| PD_cognitive_decline["PD cognitive decline"]
    DPP6_linked_neuronal_regu["DPP6-linked neuronal regulatory networks"] -->|modulates| synaptic_excitability["synaptic excitability"]
    DPP6_linked_neuronal_regu_1["DPP6-linked neuronal regulatory networks"] -->|regulates| cognitive_resilience_in_P["cognitive resilience in PD"]
    cell_type_eQTL_colocaliza["cell-type eQTL colocalization"] -->|activates| DPP6_mechanism_validation["DPP6 mechanism validation"]
    cell_state_stratification["cell-state stratification"] -->|activates| DPP6_GWAS_signal_resoluti["DPP6 GWAS signal resolution"]
    DPP6_2["DPP6"] -->|associated with| GWAS_signal["GWAS signal"]
    DPP6_linked_neuronal_regu_3["DPP6-linked neuronal regulatory networks"] -->|causes| PD_cognitive_decline_4["PD cognitive decline"]
    DPP6_5["DPP6"] -->|causes| PD_cognitive_decline_6["PD cognitive decline"]
    hippocampal_neurons["hippocampal neurons"] -->|biomarker for| prodromal_PD_changes["prodromal PD changes"]
    prefrontal_neurons["prefrontal neurons"] -->|biomarker for| prodromal_PD_changes_7["prodromal PD changes"]
    DPP6_linked_neuronal_regu_8["DPP6-linked neuronal regulatory networks"] -->|therapeutic target| PD_cognitive_decline_ther["PD cognitive decline therapeutic target"]
    proximal_molecular_phenot["proximal molecular phenotype"] -->|causes| disease_relevant_phenotyp["disease-relevant phenotype"]
    style DPP6 fill:#ce93d8,stroke:#333,color:#000
    style PD_cognitive_decline fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_linked_neuronal_regu fill:#4fc3f7,stroke:#333,color:#000
    style synaptic_excitability fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_linked_neuronal_regu_1 fill:#4fc3f7,stroke:#333,color:#000
    style cognitive_resilience_in_P fill:#4fc3f7,stroke:#333,color:#000
    style cell_type_eQTL_colocaliza fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_mechanism_validation fill:#4fc3f7,stroke:#333,color:#000
    style cell_state_stratification fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_GWAS_signal_resoluti fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_2 fill:#ce93d8,stroke:#333,color:#000
    style GWAS_signal fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_linked_neuronal_regu_3 fill:#4fc3f7,stroke:#333,color:#000
    style PD_cognitive_decline_4 fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_5 fill:#ce93d8,stroke:#333,color:#000
    style PD_cognitive_decline_6 fill:#4fc3f7,stroke:#333,color:#000
    style hippocampal_neurons fill:#4fc3f7,stroke:#333,color:#000
    style prodromal_PD_changes fill:#4fc3f7,stroke:#333,color:#000
    style prefrontal_neurons fill:#4fc3f7,stroke:#333,color:#000
    style prodromal_PD_changes_7 fill:#4fc3f7,stroke:#333,color:#000
    style DPP6_linked_neuronal_regu_8 fill:#4fc3f7,stroke:#333,color:#000
    style PD_cognitive_decline_ther fill:#4fc3f7,stroke:#333,color:#000
    style proximal_molecular_phenot fill:#4fc3f7,stroke:#333,color:#000
    style disease_relevant_phenotyp fill:#4fc3f7,stroke:#333,color:#000