TREM2 enhancement as a way to restore protective microglial response and reduce downstream tau spread requires proximal validation

graph TD
    TREM2["TREM2"] -->|modulates| microglial_response["microglial response"]
    TREM2_enhancement["TREM2 enhancement"] -->|prevents| microglial_dysfunction["microglial dysfunction"]
    TREM2_1["TREM2"] -.->|inhibits| tau_spread["tau spread"]
    TREM2_2["TREM2"] -->|modulates| AD_progression["AD progression"]
    TREM2_3["TREM2"] -->|regulates| microglial_lipid_handling["microglial lipid handling"]
    TREM2_4["TREM2"] -->|regulates| plaque_compaction["plaque compaction"]
    TREM2_5["TREM2"] -.->|inhibits| tau_propagation["tau propagation"]
    stage_dependent_timing["stage-dependent timing"] -->|modulates| TREM2_activation_efficacy["TREM2 activation efficacy"]
    TREM2_activation["TREM2 activation"] -->|causes| inflammatory_injury["inflammatory injury"]
    sess_AD_MASTER_PLAN_TREM2["sess_AD-MASTER-PLAN-TREM2-20260428030753_task_66f1207e_ctx"] -->|causal extracted| processed["processed"]
    style TREM2 fill:#ce93d8,stroke:#333,color:#000
    style microglial_response fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_enhancement fill:#ce93d8,stroke:#333,color:#000
    style microglial_dysfunction fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_1 fill:#ce93d8,stroke:#333,color:#000
    style tau_spread fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_2 fill:#ce93d8,stroke:#333,color:#000
    style AD_progression fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_3 fill:#ce93d8,stroke:#333,color:#000
    style microglial_lipid_handling fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_4 fill:#ce93d8,stroke:#333,color:#000
    style plaque_compaction fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_5 fill:#ce93d8,stroke:#333,color:#000
    style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
    style stage_dependent_timing fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_activation_efficacy fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_activation fill:#ce93d8,stroke:#333,color:#000
    style inflammatory_injury fill:#4fc3f7,stroke:#333,color:#000
    style sess_AD_MASTER_PLAN_TREM2 fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000