ER-mitochondria contact-site dysfunction in neurodegeneration

🧪 Hypothesis Details

Altered mitochondria-associated membranes may disrupt calcium transfer, lipid synthesis, ROS handling, and apoptotic thresholds in neurodegeneration. The hypothesis needs disease-, cell-type-, and stage-specific directionality because either excessive coupling, insufficient coupling, or altered contact composition could be pathogenic.

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↻ Rerun processing chain

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