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How do [C9orf72](/genes/c9orf72) repeat expansions drive both FTLD and ALS phenotypes, and what determines clinical presentation?
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open question
Created: 2026-04-25T20:26:27
By: backfill_open_questions
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ID: open_question-5187de3d-bd45-472e-885d-c5
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open
Wiki: diseases-frontotemporal-lobar-degeneration
How do [C9orf72](/genes/c9orf72) repeat expansions drive both FTLD and ALS phenotypes, and what determines clinical presentation?
Importance Elo
1500
Field Rank
Rank #156 in diseases
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page diseases-frontotemporal-lobar-degeneration
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▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:26:27.249436'} |
| field_tag | diseases |
| source_id | diseases-frontotemporal-lobar-degeneration |
| sub_field | frontotemporal-lobar-degeneration |
| source_kind | wiki |
| question_hash | 7d74589cd0d340999241a2bb4f7ab94b0d6752b197f3a6d353a3056ed13a7b7a |
| question_text | How do [C9orf72](/genes/c9orf72) repeat expansions drive both FTLD and ALS phenotypes, and what determines clinical presentation? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page diseases-frontotemporal-lobar-degeneration |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
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Outgoing
1
0 supporting
0 contradicting
0 neutral
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