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TREM2 variants in Alzheimer's disease.
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📄 Paper Details
TREM2 variants in Alzheimer's disease.
Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva et al.
Abstract
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. METHODS: We used genome, exome, and Sanger sequencing to analyze the genetic variability in TREM2 in a series of 1092 patients with Alzheimer's disease and 1107 controls (the discovery set). We then performed a meta-analysis on imputed data for the TREM2 variant rs75932628 (pred...
▸Metadata
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
45%
Debates
0
Incoming
9
Outgoing
0
0 supporting
0 contradicting
0 neutral
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