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APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model.
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ID: paper-40307424
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APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model.
["Vanherle S", "Janssen A", "Guti\u00e9rrez de Rav\u00e9 M", "Janssen B", "Lodder C", "Botella Lucena P", "Kessels S", "Hardy J", "Vandeput E", "Wang Y"]
Abstract
In AD, amyloid pathology (A) precedes progressive development of tau pathology (T) and neurodegeneration (N), with the latter (T/N) processes associated with symptom progression. Recent anti-amyloid beta (Aβ) clinical trials raise hope but indicate the need for multi-targeted therapies, to effectively halt clinical AD and ATN pathology progression. APOE-related putative protective mutations (including APOE3Christchurch, RELN-COLBOS) were recently identified in case reports with exceptionally hig...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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