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Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.
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ID: paper-41035073
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Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.
Castanho I, Naderi Yeganeh P, Boix CA, Morgan SL, Mathys H, Prokopenko D, White B, Soto LM, Pegoraro G, Shah S, Ploumakis A, Kalavros N, Bennett DA, Lange C, Kim DY, Bertram L, Tsai LH, Kellis M, Tanz
Abstract
BACKGROUND: A significant proportion of individuals maintain cognition despite extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals could reveal therapeutic targets for AD. METHODS: This study defines molecular and cellular signatures of cognitive resilience by integrating bulk RNA and single-cell transcriptomic data with genetics across multiple brain regions. We analyzed data from the Religious Order ...
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