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Human MKP-3 isoforms display differential structural and functional profiles.
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ID: paper-41865406
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Human MKP-3 isoforms display differential structural and functional profiles.
Mori Sequeiros Garcia MM, Nudler S, Bigi MM, Cohen Sabban JM, Poderoso C, Maloberti PM, Paz C
Abstract
Mitogen-activated protein kinase (MAPK) phosphatases [MKPs, also known as dual-specificity phosphatases (DUSPs)] regulate MAPKs -key mediators of cellular processes such as proliferation, differentiation, and survival- by dephosphorylating the threonine and tyrosine residues required for MAPK activation. MKP-3/DUSP6 is an ERK-selective phosphatase that has also been reported to regulate the transcription factor FOXO1. The full-length MKP-3 transcript has been shown to encode the MKP-3L protein, ...
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📊 Evidence Profile
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