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Figure 5 — Dopaminergic Epistases in Schizophrenia.
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Created: 2026-04-21T18:29:40
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Figure 5Figure 5
This review highlights two potential interactive effects of the COMTxDRD2 gene combination. The Japanese population (illustrated on the right) appears vulnerable to high COMT activity in the prefrontal brain (associated with the Val/Val genotype), combined with lower DRD2 receptor availability (associated with the A1 variant). This is functionally translated by lower prefrontal dopamine levels and higher striatal DA activity. The opposite effect may appear in Russians, however (left side), where lower COMT activity and higher DRD2 autoreceptor function led to higher prefrontal DA and lower striatal DA levels, and appear to represent a risk pattern [ 112 ].
▸Metadata
| pmid | 30ca96c6-1e77-4791-83b7-6ee8afff3f62 |
| caption | This review highlights two potential interactive effects of the COMTxDRD2 gene combination. The Japanese population (illustrated on the right) appears vulnerable to high COMT activity in the prefronta |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11592377/bin/brainsci-14-01089-g005.jpg |
| paper_title | Dopaminergic Epistases in Schizophrenia. |
| figure_label | Figure 5 |
| figure_number | 5 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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