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Fig. 7: Lithium upregulates brain endothelial Wnt/β-catenin signaling and attenuates LPS...
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Created: 2026-04-16T11:31:42
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ID: paper-fig-39427196-7
Fig. 7Figure 7
Lithium upregulates brain endothelial Wnt/β-catenin signaling and attenuates LPS-induced BBB leakage and neuroinflammation. A , Schematic illustration of experimental design. The Wnt/β-catenin signaling pathway agonist Lithium (3 mmol/kg) or vehicle control (saline) was intraperitoneally (i.p.) injected to mice at 30 min after LPS or saline injection. B , Mortality rate of mice at 24 h following vehicle ( n = 12 mice), LPS + vehicle ( n = 14 mice), or LPS + LiCl ( n = 12 mice) treatment. C , Body weight change of mice at 24 h following vehicle ( n = 8 mice), LPS + vehicle ( n = 9 mice), or LPS + LiCl ( n = 7 mice) treatment. D , Co-immunofluorescence staining of active β-catenin (non-phosphorylated) and CD31 in the brain cortex and its quantifications. Active β-catenin signal in endothelial cells was selectively quantified. E , Co-immunofluorescence staining of LEF1 and CD31 in the brain cortex and its quantifications. F , Co-immunofluorescence staining of mouse plasma IgG a
▸Metadata
| doi | |
| pmcid | PMC11491032 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig7_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-16T11:31:41.992164'} |
| caption | Lithium upregulates brain endothelial Wnt/β-catenin signaling and attenuates LPS-induced BBB leakage and neuroinflammation. A , Schematic illustration of experimental design. The Wnt/β-catenin signali |
| paper_id | 39427196 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig7_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 7 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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