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Figure 3.: Dysregulation of genes and pathways in synucleinopathy patients’ appendices. (A)...
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Created: 2026-04-28T00:22:23
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ID: paper-fig-41279937-3
Figure 3.Figure 3
Dysregulation of genes and pathways in synucleinopathy patients’ appendices. (A) Volcano plot depicting differentially expressed genes in the appendix of synucleinopathy patients (n=11) as compared to controls (n=13). The upregulated (red) and downregulated (blue) genes with log2fold-change >2 (p-adj <0.05) are highlighted. The genes with no significant (NS) change are shown as grey dots. Gene Set Enrichment Analysis (GSEA) of Gene Ontology (GO) terms identified pathways affected by the DE genes in PD appendices vs controls. (B) GO-Biological Process, (C) GO-Cellular Components, and (D) GO-Molecular Function show activated (left) and suppressed (right) pathways in the PD appendix. Most of the DE genes and dysregulated pathways in synucleinopathy appendix contribute to immune responses, protein folding and cilia-related processes.
▸Metadata
| doi | |
| pmcid | PMC12632551 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12632551/bin/nihpp-2025.10.07.680938v1-f0003.jpg', 'type': 'external', 'tracked_at': '2026-04-28T07:22:23.588491'} |
| caption | Dysregulation of genes and pathways in synucleinopathy patients’ appendices. (A) Volcano plot depicting differentially expressed genes in the appendix of synucleinopathy patients (n=11) as compared t |
| paper_id | 41279937 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12632551/bin/nihpp-2025.10.07.680938v1-f0003.jpg |
| image_path | |
| description | |
| figure_label | Figure 3. |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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