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Fig. 4: Altered transcriptional programs and predicted Chr. 21 TF targets in the develop...
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Created: 2026-04-27T05:03:34
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Fig. 4Figure 12
Altered transcriptional programs and predicted Chr. 21 TF targets in the developing DS cortex are partially recapitulated in vitro and rescued by TF modulation. a , Experimental approach for modeling DS neurodevelopment and normalizing Chr. 21 TF expression in vitro. b , Fraction of differential genes per tissue population also detected in vitro. Red and blue boxes indicate genes upregulated or downregulated both in fetal tissue and in vitro. c , Expression changes in DS versus CON for genes differentially expressed in fetal tissue linked to the GO term ‘forebrain development’. DESeq2 analysis with the likelihood ratio test (LRT) was used to assess group effect across paired DS versus CON technical and biological replicates (between three and ten RNA samples from wells of paired side-by-side differentiated DS or CON cells per condition from n = 6, 2, 3 and 1 independent differentiation experiments for iNPC_C9_C13, iNPC_DS2U_DS1, iNEU_C9_C13 and iNEU_DS2U_DS1, respectively; Methods
▸Metadata
| doi | 10.1038/s41591-026-04211-1 |
| pmcid | PMC13004680 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC13004680/bin/41591_2026_4211_Fig4_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:34.035020'} |
| caption | Altered transcriptional programs and predicted Chr. 21 TF targets in the developing DS cortex are partially recapitulated in vitro and rescued by TF modulation. a , Experimental approach for modeling |
| paper_id | 9354c026-33f1-4701-b47d-64ce038e7e37 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13004680/bin/41591_2026_4211_Fig4_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 4 |
| figure_number | 12 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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