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Fig. 5: Transplanted human neural cells reveal DS molecular and cellular phenotypes not ...
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Created: 2026-04-27T05:03:34
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Fig. 5Figure 14
Transplanted human neural cells reveal DS molecular and cellular phenotypes not recapitulated in vitro and emerging at later stages of fetal development. a , Experimental approach for modeling DS neurodevelopment in vivo. b , Mapping of CON and DS excitatory lineage transplanted cells to fetal tissue populations (UMAP plot). c , Cell abundance in CON and DS transplants. Barplot showing individual samples ( n = 8 for CON and n = 4 for DS), mean ± s.d. and FDR for sccomp compositional analyses 71 (other clusters FDR > 0.05). Dotted boxes highlight selected populations: FDR < 0.05 (black) or FDR > 0.05 (gray). d , Fraction of differential genes per cluster in fetal tissue also detected in grafts and in vitro. Comparisons showing concordant changes in fetal tissue versus models, and fraction of discordantly regulated genes in vitro versus fetal tissue are highlighted. DESeq2 analysis for grafts with LRT test by cluster with correction for sequencing technology, threshold P adj < 0
▸Metadata
| doi | 10.1038/s41591-026-04211-1 |
| pmcid | PMC13004680 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC13004680/bin/41591_2026_4211_Fig5_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:34.179813'} |
| caption | Transplanted human neural cells reveal DS molecular and cellular phenotypes not recapitulated in vitro and emerging at later stages of fetal development. a , Experimental approach for modeling DS neur |
| paper_id | 9354c026-33f1-4701-b47d-64ce038e7e37 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13004680/bin/41591_2026_4211_Fig5_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 5 |
| figure_number | 14 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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