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Fig. 6: PDE4 inhibitor attenuates TAC-induced cardiac hypertrophy and heart failure . Mi...
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Fig. 6Figure 7
PDE4 inhibitor attenuates TAC-induced cardiac hypertrophy and heart failure . Mice were subjected to TAC or sham operation and administered vehicle or roflumilast (1 mg/kg/day) via oral gavage for 6 weeks. Ejection fraction ( A ) and fractional shortening ( B ) were measured using echocardiography at 6 weeks after TAC; n = 9 mice per group. C, Representative images showing gross cardiac morphology of the heart. D, Representative images of HE, staining of WGA, TUNEL, DHE and MitoSOX and transmission electron microscopy in mouse hearts in the indicated groups. E, CSA was assessed using WGA staining; n = 100 cells per heart and 3 hearts per group. Quantification of TUNEL ( F ) and DHE ( G ) staining, 3–5 random fields per heart; n = 3 mice per group. TUNEL, Scale bar, 50 μm; DHE, Scale bar, 100 μm. H. Quantitative analysis of relative MDA levels, n = 5 mice per group. I, Mitochondrial ROS level was measured using MitoSOX staining in isolated adult cardiomyocytes from indicated g
▸Metadata
| doi | 10.1016/j.redox.2025.103563 |
| pmcid | PMC11909752 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr6.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:31.407343'} |
| caption | PDE4 inhibitor attenuates TAC-induced cardiac hypertrophy and heart failure . Mice were subjected to TAC or sham operation and administered vehicle or roflumilast (1 mg/kg/day) via oral gavage for 6 w |
| paper_id | 9a10f9ee-2201-47b2-a4ca-b169666a53d9 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr6.jpg |
| image_path | |
| description | |
| figure_label | Fig. 6 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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