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Fig. 8: Schematic of the proposed mechanism for chronic adrenergic stimulation induced h...
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Fig. 8Figure 9
Schematic of the proposed mechanism for chronic adrenergic stimulation induced heart failure via cAMP-PKA-PDE4D signaling pathway and protective mechanism of PDE4D inhibition . Sustained adrenergic activation upregulates PDE4D expression via cAMP-PKA signaling, which in turn reduces cAMP-PKA activity, resulting in cardiomyocyte hypertrophy and mitochondrial injury via inhibition of CREB-SIRT1 signaling-mediated mitophagy. Pharmacological inhibition or knockdown of PDE4D reduced cAMP degradation and activates PKA-CREB-SIRT1 signaling, leading to a restoration of PINK1/Parkin-mediated mitophagy in cardiomyocytes, which may contribute to improvement of cardiac function and hypertrophy.
▸Metadata
| doi | 10.1016/j.redox.2025.103563 |
| pmcid | PMC11909752 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr8.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:31.488444'} |
| caption | Schematic of the proposed mechanism for chronic adrenergic stimulation induced heart failure via cAMP-PKA-PDE4D signaling pathway and protective mechanism of PDE4D inhibition . Sustained adrenergic ac |
| paper_id | 9a10f9ee-2201-47b2-a4ca-b169666a53d9 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr8.jpg |
| image_path | |
| description | |
| figure_label | Fig. 8 |
| figure_number | 9 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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