🖼
Fig. 1 — Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc
active
paper figure
Created: 2026-04-21T18:29:40
By: paper_figures_tool
Quality:
50%
🔗 External
ID: paper-fig-paper-3223c7eb7722-1
Fig. 1Figure 1
Schematic diagram of the separating MN patch as a pathological microenvironment-responsive peptide prodrug delivery platform. a Schematic illustration of the fabrication process of a separating MN patch via a step-by-step method. GelMA was mixed with peptide prodrug and photo-initiator to form a precursor solution, poured into MN moulds and crosslinked by UV light. The gelatin solution was then secondarily perfused into the MN mould to form MN base layer. After drying and curing, MN patches were peeled off from the MN mould. b Schematic illustration of the drug-loaded MNs on HS treatment. After crosslinked drug-loaded tips penetrate HS tissue, the MN base layer is removed. The slow and sustained drug release from MN tips in response to the HS pathological microenvironment leads to fibroblast apoptosis and down-regulation of collagen fibril organization, simultaneously stimulating the inflammatory response and mediating keratinocyte differentiation to inhibit collagen synthesis of HS
▸Metadata
| pmid | paper-3223c7eb7722 |
| caption | Schematic diagram of the separating MN patch as a pathological microenvironment-responsive peptide prodrug delivery platform. a Schematic illustration of the fabrication process of a separating MN pa |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC10917775/bin/41467_2024_46328_Fig1_HTML.jpg |
| paper_title | Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment. |
| figure_label | Fig. 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.