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Fig. 3 — Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-8592a1d224cf-4
Fig. 3Figure 4
Systems pharmacology reveals hemodynamic and endothelial remodeling mechanisms of PF in alleviating microcirculatory dysfunction during CRF (A–B) KEGG (A) and GO (B) enrichment analyses of overlapping genes between PF-predicted targets and CRF-related genes (n = 125). KEGG analysis revealed significant enrichment in vascular-related pathways, including fluid shear stress and atherosclerosis, HIF-1 signaling, and relaxin signaling pathways. GO analysis showed associations with biological processes such as response to hypoxia, platelet alpha granule formation, and blood microparticle generation. (C–D) KEGG (C) and GO (D) enrichment of PF targets intersecting with microcirculation-related genes (n = 78). Identified pathways were consistent with CRF-related analyses, while GO terms included endothelial cell migration and protein tyrosine kinase activity, suggesting a role for PF in endothelial activation and remodeling. (E–F) KEGG (E) and GO (F) enrichment analyses of PF targets overlappin
▸Metadata
| pmid | paper-8592a1d224cf |
| caption | Systems pharmacology reveals hemodynamic and endothelial remodeling mechanisms of PF in alleviating microcirculatory dysfunction during CRF (A–B) KEGG (A) and GO (B) enrichment analyses of overlapping |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13001056/bin/gr3.jpg |
| paper_title | Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic approach for renal fibrosis. |
| figure_label | Fig. 3 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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