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FIGURE 1 — The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p
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Created: 2026-04-21T18:29:40
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FIGURE 1Figure 1
The composition of DU145 adhesion (IACs and ECM) proteins. (A) Analysis of the relative cell radiosensitivity of DU145 radioresistant (RR) and parental (P) cells using radiobiological colony formation assay. Data are mean ± SD; * p < 0.05. (B) The cell adhesion assay (duration 2 h) reveals that DU145 RR cells show enhanced adhesion properties than DU145 P cells to their own, cell-derived matrix. Data are mean ± SD. (C) Protein - protein interaction network of integrin nexus identified through mass spectrometry of proteins isolated from DU145 P cells. Proteins that passed the threshold of spectral count SC ≥ 4 in two out of three replicas in DU145 P cells are shown (340 of 910 proteins in total). The matrisome proteins are categorized according to the MatrisomeDB. In addition, TFPI2, PLAUR, QSOX1 (both P and RR cells), and CCDC80 (only RR cells) were recognized as potential ECM proteins, but they are not included under the matrisome category because this figure aligns with the Ma
▸Metadata
| pmid | paper-de0f65fde5fe |
| caption | The composition of DU145 adhesion (IACs and ECM) proteins. (A) Analysis of the relative cell radiosensitivity of DU145 radioresistant (RR) and parental (P) cells using radiobiological colony formati |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11325029/bin/fcell-12-1452463-g001.jpg |
| paper_title | The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells. |
| figure_label | FIGURE 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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