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Extended Data Fig. 9. — Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl
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Created: 2026-04-21T18:29:40
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Extended Data Fig. 9.Figure 9
Sarcolipin abundance is regulated by TUG and is decreased in diet-induced insulin resistance. a, WT and MTKO mice were housed at 30° C from the time of weaning. At age 20 weeks, mice were fasted, treated with IP insulin-glucose or saline control, and sacrificed 3 h later. Hindlimb muscle lysates were immunoblotted as indicated. Data from replicates of this experiment were quantified and are plotted in Fig. 4b . b, WT and UBX mice were treated with IP insulin-glucose, or saline control, sacrificed after 30 min., and quadriceps muscles were immunoblotted as indicated. c,d, WT and MTKO mice were treated with IP insulin-glucose, or saline control, and sacrificed after 30 min. Hindlimb muscles were used for chromatin immunoprecipitation using PGC-1α ( c ) and PPARγ ( d ) antibodies, as indicated. PCR was used to detect an amplicon at −200 nucleotides relative to the sarcolipin transcription start site. e, WT mice were fed regular chow (RC) or a high-fat diet (HFD) for 3 weeks, then
▸Metadata
| pmid | paper-e86f071aad74 |
| caption | Sarcolipin abundance is regulated by TUG and is decreased in diet-induced insulin resistance. a, WT and MTKO mice were housed at 30° C from the time of weaning. At age 20 weeks, mice were fasted, tre |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC7990718/bin/nihms-1671263-f0016.jpg |
| paper_title | Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. |
| figure_label | Extended Data Fig. 9. |
| figure_number | 9 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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