🖼
Figure 2 from PMID:41890637
active
paper figure
Created: 2026-04-13T06:15:46
By: unknown
Quality:
95%
✓ SciDEX
ID: paper-figure-41890637-2
Figure 2Figure 2
Key adhesion molecules at excitatory and inhibitory synapses and the importance of their balance. This figure summarizes major adhesion molecules and scaffold/adaptor proteins at excitatory and inhibitory synapses. At excitatory synapses (left), presynaptic Neurexin1 binds postsynaptic Neuroligin1, with PSD-95 as a central scaffold; Cadm1 contributes to spine formation and synapse stabilization. At inhibitory synapses (right), postsynaptic Neuroligin2 organizes an inhibitory scaffold centered on Gephyrin. Balanced excitatory and inhibitory synaptic organization is essential for normal circuit function and plasticity, and its disruption is implicated in neurological disorders. The presynaptic scaffold/adaptor complex includes CASK, Mint, and other synaptic organizing molecules. In contrast, cytoskeletal adaptor/structural proteins at presynaptic sites include Ankyrin-G, Spectrin, F-actin, and actin-associated protains. AMPAR, AMPA-type glutamate receptor; ARHGEF9, collybistin; Cadm1, ce
▸Metadata
| pmid | 41890637 |
| pmc_id | PMC13013429 |
| caption | Key adhesion molecules at excitatory and inhibitory synapses and the importance of their balance. This figure summarizes major adhesion molecules and scaffold/adaptor proteins at excitatory and inhibi |
| image_url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013429/figure/F2/ |
| figure_label | Figure 2 |
| figure_number | 2 |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.