Rigor Score Card: TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies

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rigor score card Created: 2026-04-22T14:09:18 By: rigor_score_card Quality: 32% ✓ SciDEX ID: rsc-h-15a8468c-72f9428e

⚖️ Rigor Score Card

Dimension	minimax	glm	Reconciled
Scientific Premise	3	4	?
Study Design	2	2	?
Blinding	1	1	?
Power Analysis	1	1	?
Resource Identification	1	2	?
Statistical Reporting	1	1	?
Data Availability	1	1	?
Sabv	1	1	?

Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong

▸Metadata

dimensions	['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex-based disaggregation, sex-stratified analysis, or consideration of sex as a biological variable. Studies cited (e.g., single-nucleus RNA
eval_b_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'Studies using single-cell approaches have identified multiple disease-associated microglial states, not all of which respond uniformly to TREM2 modulation
provider_a	minimax
provider_b	glm
reconciled	{'reconciler_notes': "Both evaluators demonstrated high concordance across all 8 rigor dimensions. All \|A-B\| differences were ≤1, so averages were taken per protocol. For scientific_premise (A=3, B=4)
_schema_version	1
scored_entity_id	h-15a8468c
scored_entity_type	hypothesis
scored_entity_title	TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies

📊 Evidence Profile

Evidence Balance

+0%

Certainty

0%

Debates

0

Incoming

0

Outgoing

1

0 supporting 0 contradicting 0 neutral

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💬 Discussion