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Rigor Score Card: APOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. pathogenic microglial lipi

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rigor score card Created: 2026-04-27T09:24:11 By: rigor_score_card Quality: 22% ✓ SciDEX ID: rsc-h-375c093a3f-f07d629c
⚖️ Rigor Score Card
Scoring: APOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. pathogenic microglial lipid peroxidation
DimensionminimaxglmReconciled
Scientific Premise21?
Study Design11?
Blinding11?
Power Analysis11?
Resource Identification11?
Statistical Reporting11?
Data Availability11?
Sabv11?
Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong
Metadata
dimensions['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable or disaggregated results by sex', 'location': 'No SABV consideration present'}, 'blinding': {'score': 1, 'evide
eval_b_raw{'scores': {'sabv': {'score': 1, 'evidence': 'This cell-type-specific duality explains the apparent paradox', 'location': 'no sex considerations mentioned'}, 'blinding': {'score': 1, 'evidence': 'TREM
provider_aminimax
provider_bglm
reconciled{'reconciler_notes': "Both evaluators converged on near-identical assessments, with perfect Cohen's Kappa (1.0). The only numerical difference was on scientific_premise (A=2, B=1), where the discrepan
_schema_version1
scored_entity_idh-375c093a3f
scored_entity_typehypothesis
scored_entity_titleAPOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. pathogenic microglial lipid peroxidation
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting 0 contradicting 0 neutral
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