Rigor Score Card: MITF Acts as the Primary Transcriptional Effector Downstream of HDAC1/2 Deletion, Driving the DAM2 L

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rigor score card Created: 2026-04-27T18:42:54 By: rigor_score_card Quality: 30% ✓ SciDEX ID: rsc-h-440f8a5f-1a0defa6

⚖️ Rigor Score Card

Dimension	minimax	glm	Reconciled
Scientific Premise	3	3	?
Study Design	1	1	?
Blinding	1	1	?
Power Analysis	1	1	?
Resource Identification	2	2	?
Statistical Reporting	2	2	?
Data Availability	1	1	?
Sabv	1	1	?

Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong

▸Metadata

dimensions	['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable or disaggregation by sex', 'location': 'Not applicable to this hypothesis document'}, 'blinding': {'score': 1,
eval_b_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable, no disaggregation by sex, and no discussion of sex-specific effects in the mechanistic model despite involving
provider_a	minimax
provider_b	glm
reconciled	{'reconciler_notes': 'Perfect inter-rater agreement (κ=1.0) across all 8 dimensions. Both evaluators independently assessed this as a mechanistic hypothesis document lacking primary experimental data,
_schema_version	1
scored_entity_id	h-440f8a5f
scored_entity_type	hypothesis
scored_entity_title	MITF Acts as the Primary Transcriptional Effector Downstream of HDAC1/2 Deletion, Driving the DAM2 Lysosomal Program Through De-repression of Phagocytic Enhancers

📊 Evidence Profile

Evidence Balance

+0%

Certainty

0%

Debates

0

Incoming

0

Outgoing

0

0 supporting 0 contradicting 0 neutral

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💬 Discussion