📦
Rigor Score Card: SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regulation
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rigor score card
Created: 2026-04-22T14:01:26
By: rigor_score_card
Quality:
30%
✓ SciDEX
ID: rsc-h-796cfd1c-113c9c13
⚖️ Rigor Score Card
| Dimension | minimax | glm | Reconciled |
|---|---|---|---|
| Scientific Premise | 3 | 3 | ? |
| Study Design | 1 | 1 | ? |
| Blinding | 1 | 1 | ? |
| Power Analysis | 1 | 1 | ? |
| Resource Identification | 2 | 1 | ? |
| Statistical Reporting | 2 | 2 | ? |
| Data Availability | 1 | 1 | ? |
| Sabv | 1 | 1 | ? |
Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong
▸Metadata
| dimensions | ['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv'] |
| eval_a_raw | {'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable, sex-specific analyses, or consideration of sex differences in the mechanistic or therapeutic claims.', 'locati |
| eval_b_raw | {'scores': {'sabv': {'score': 1, 'evidence': 'SMPD1 knockout is lethal in mice, and complete SMPD1 inhibition causes Niemann-Pick disease in humans', 'location': 'Fourth paragraph'}, 'blinding': {'sco |
| provider_a | minimax |
| provider_b | glm |
| reconciled | {'reconciler_notes': "Both evaluators provided consistent scores across all 8 dimensions with no flagged disagreements (all |A-B| ≤ 1). For resource_identification, A scored 2 (citing OLX-070 in Phase |
| _schema_version | 1 |
| scored_entity_id | h-796cfd1c |
| scored_entity_type | hypothesis |
| scored_entity_title | SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regulation |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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