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Rigor Score Card: VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease sta

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rigor score card Created: 2026-04-22T14:11:22 By: rigor_score_card Quality: 25% ✓ SciDEX ID: rsc-h-9bcba57f3f-f10202db
⚖️ Rigor Score Card
Scoring: VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease stages
DimensionminimaxglmReconciled
Scientific Premise21?
Study Design11?
Blinding11?
Power Analysis11?
Resource Identification21?
Statistical Reporting11?
Data Availability11?
Sabv11?
Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong
Metadata
dimensions['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw{'scores': {'sabv': {'score': 1, 'evidence': 'This mechanism operates pan-cortically and across disease stages, making it the most broadly applicable therapeutic target.', 'location': 'Sentence 3'}, '
eval_b_raw{'scores': {'sabv': {'score': 1, 'evidence': 'This mechanism operates pan-cortically and across disease stages', 'location': 'Source text, paragraph 1'}, 'blinding': {'score': 1, 'evidence': 'amplifyi
provider_aminimax
provider_bglm
reconciled{'reconciler_notes': 'Both evaluators independently identified the source text as promotional/marketing material lacking methodological content. Minor score differences on scientific_premise (2 vs 1)
_schema_version1
scored_entity_idh-9bcba57f3f
scored_entity_typehypothesis
scored_entity_titleVPS35 retromer activation prevents endosomal tau templating across all brain regions and disease stages
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting 0 contradicting 0 neutral
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