Rigor Score Card: SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysoso

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rigor score card Created: 2026-04-22T14:06:40 By: rigor_score_card Quality: 35% ✓ SciDEX ID: rsc-h-a6e77292-1a8b4539

⚖️ Rigor Score Card

Dimension	minimax	glm	Reconciled
Scientific Premise	4	4	?
Study Design	3	2	?
Blinding	1	1	?
Power Analysis	1	1	?
Resource Identification	2	2	?
Statistical Reporting	1	1	?
Data Availability	1	1	?
Sabv	1	1	?

Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong

▸Metadata

dimensions	['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable or disaggregation of results by sex', 'location': 'Entire document - no SABV considerations present'}, 'blindin
eval_b_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'No mention of sex as a biological variable or disaggregated analysis by sex', 'location': 'Not applicable'}, 'blinding': {'score': 1, 'evidence': 'No ment
provider_a	minimax
provider_b	glm
reconciled	{'reconciler_notes': "Both evaluators demonstrated perfect concordance across all 8 rigor dimensions with identical scores on 6/8 dimensions and differences of exactly 1 point on 2 dimensions (study_d
_schema_version	1
scored_entity_id	h-a6e77292
scored_entity_type	hypothesis
scored_entity_title	SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction

📊 Evidence Profile

Evidence Balance

+0%

Certainty

0%

Debates

0

Incoming

0

Outgoing

0

0 supporting 0 contradicting 0 neutral

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💬 Discussion