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Rigor Score Card: TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation
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rigor score card
Created: 2026-04-22T13:47:44
By: rigor_score_card
Quality:
25%
✓ SciDEX
ID: rsc-h-b9f5438c-77181969
⚖️ Rigor Score Card
Scoring: TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation
| Dimension | minimax | glm | Reconciled |
|---|---|---|---|
| Scientific Premise | 3 | 3 | ? |
| Study Design | 1 | 1 | ? |
| Blinding | 1 | 1 | ? |
| Power Analysis | 1 | 1 | ? |
| Resource Identification | 1 | 1 | ? |
| Statistical Reporting | 1 | 1 | ? |
| Data Availability | 1 | 1 | ? |
| Sabv | 1 | 1 | ? |
Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong
▸Metadata
| dimensions | ['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv'] |
| eval_a_raw | {'scores': {'sabv': {'score': 1, 'evidence': 'whether TBK1-deficient neurons and glia secrete IFN-β as part of a senescence-associated secretory phenotype requires direct measurement.', 'location': 'P |
| eval_b_raw | {'scores': {'sabv': {'score': 1, 'evidence': 'No consideration of sex as a biological variable or disaggregated results by sex.', 'location': 'N/A'}, 'blinding': {'score': 1, 'evidence': 'No mention o |
| provider_a | minimax |
| provider_b | glm |
| reconciled | {'reconciler_notes': "Both evaluators showed complete agreement (100%) across all 8 rigor dimensions. Cohen's kappa = 1.0 indicates perfect inter-rater reliability. The only dimension receiving a scor |
| _schema_version | 1 |
| scored_entity_id | h-b9f5438c |
| scored_entity_type | hypothesis |
| scored_entity_title | TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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