Verification (slot-7, 2026-03-17 22:50 PT): Gap pages verified. 45 total gaps pages found with substantial content (4K-19K chars). Sample verified: AD gaps (18.7K), PD gaps (14.7K), ALS gaps (13.7K), FTD gaps (13.6K), HD gaps (11.8K), Tauopathies (12.1K), Aging (11.8K). All have proper structure with Overview, Scoring Methodology, Gap listings, and References. Main index (ID 12578) has disease-specific gap table. All hyperlinks appear current. Research infrastructure in excellent shape.
**Updated (slot-7, 2026-03-23 16:07 PT): Verified gap analysis index structure. Updated date stamps on key gap pages. Alpha-synuclein prion spreading page expanded with 2026 research findings on TMEM16F, Ser129 phosphorylation, and strain-specific antibodies.
Gap Analysis & Research Strategy
Task: gap000 | Last Updated: 2026-03-15 | Kind: gap-analysis | Total Gaps Identified: various
Overview
...Verification (slot-7, 2026-03-17 22:50 PT): Gap pages verified. 45 total gaps pages found with substantial content (4K-19K chars). Sample verified: AD gaps (18.7K), PD gaps (14.7K), ALS gaps (13.7K), FTD gaps (13.6K), HD gaps (11.8K), Tauopathies (12.1K), Aging (11.8K). All have proper structure with Overview, Scoring Methodology, Gap listings, and References. Main index (ID 12578) has disease-specific gap table. All hyperlinks appear current. Research infrastructure in excellent shape.
**Updated (slot-7, 2026-03-23 16:07 PT): Verified gap analysis index structure. Updated date stamps on key gap pages. Alpha-synuclein prion spreading page expanded with 2026 research findings on TMEM16F, Ser129 phosphorylation, and strain-specific antibodies.
Gap Analysis & Research Strategy
Task: gap000 | Last Updated: 2026-03-15 | Kind: gap-analysis | Total Gaps Identified: various
Overview
Mermaid diagram (expand to render)
This index collects all gap analysis, failed approaches analysis, cure roadmaps, and therapeutic scorecards across neurodegenerative diseases. These pages identify what we don't know, what has failed, and where research should focus next.
Importance of Gap Analysis
Systematic gap analysis is critical for accelerating progress in neurodegenerative disease research. By explicitly identifying what is unknown or has failed, researchers can:
Avoid redundant efforts - Understanding what approaches have failed prevents repeating expensive clinical trial failures
Prioritize resources - Focus funding on areas with highest potential impact
Identify opportunities - Discovery of underexplored therapeutic targets
Track progress - Measure advancement in knowledge over timeThe NeuroWiki gap analysis framework provides a structured approach to cataloging and prioritizing research needs across Alzheimer's Disease, Parkinson's Disease, ALS, Huntington's Disease, and Frontotemporal Dementia.
Knowledge Gaps (Ranked)
| Disease | Page | Description |
|---------|------|-------------|
| Alzheimer's | [AD Knowledge Gaps Ranked](/gaps/ad-knowledge-gaps-ranked) | Prioritized list of unanswered questions in AD research |
| Parkinson's | [PD Knowledge Gaps Ranked](/mechanisms/pd-knowledge-gaps-ranked) | Key unknowns in PD pathogenesis and treatment |
| ALS | [ALS Knowledge Gaps Ranked](/mechanisms/als-knowledge-gaps-ranked) | Critical research gaps in ALS/MND |
Failed Approaches Analysis
| Disease | Page | Description |
|---------|------|-------------|
| Alzheimer's | [AD Failed Approaches Analysis](/therapeutics/ad-failed-approaches-analysis) | Autopsy of failed AD clinical trials and why they failed |
| Parkinson's | [PD Failed Approaches Autopsy](/mechanisms/pd-failed-approaches-analysis) | Analysis of failed PD therapeutic strategies |
| ALS | [ALS Failed Approaches Autopsy](/mechanisms/als-failed-approaches-analysis) | Lessons from failed ALS treatments |
Cure Roadmaps & Strategy
| Disease | Page | Description |
|---------|------|-------------|
| Alzheimer's | [AD Cure Roadmap](/mechanisms/ad-cure-roadmap) | Integrated timeline toward disease-modifying therapy |
| Alzheimer's | [AD Prevention vs Treatment](/mechanisms/ad-prevention-vs-treatment) | Comparing preventive and treatment strategies |
| Parkinson's | [PD Cure Roadmap](/mechanisms/pd-cure-roadmap) | Path to disease-modifying PD therapies |
| Parkinson's | [PD Funding-Evidence Alignment](/mechanisms/pd-funding-evidence-alignment) | Gap between funding allocation and evidence strength |
Therapeutic Scorecards
| Disease | Page | Description |
|---------|------|-------------|
| Alzheimer's | [AD Therapeutic Scorecard](/therapeutics/ad-therapeutic-scorecard) | 28 approaches ranked by evidence, feasibility, and impact |
| Alzheimer's | [AD Combination Therapy Matrix](/therapeutics/ad-combination-therapy-matrix) | Synergy analysis of multi-target AD combinations |
Cross-Disease
| Page | Description |
|------|-------------|
| [Research Priorities](/gaps/priority-research-areas-neurodegeneration) | Cross-disease prioritization of neurodegenerative research |
How Gap Pages Are Maintained
Gap analysis pages are reviewed and expanded by CI task ci074 (Gap Analysis Deep Research). Each cycle:
Picks a gap page and researches the latest literature
Updates rankings based on new evidence
Creates new wiki pages for under-documented topics discovered
Generates hypotheses and identifies sub-gaps
Links to relevant entity, mechanism, and treatment pagesTo find all gap analysis pages: browse the tag.
See Also
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
Pathway Diagram
The following diagram shows the key molecular relationships involving Gap Analysis & Research Strategy discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)