| Property | Value | |---------|-------| | Gene Symbol | GALR1 | | Full Name | Galanin Receptor 1 | | Chromosome | 18q23 | | NCBI Gene ID | [25826](https://www.ncbi.nlm.nih.gov/gene/25826) | | Ensembl ID | ENSG00000134390 | | UniProt ID | [P47211](https://www.uniprot.org/uniprot/P47211) | | OMIM | 600041 | | Protein Length | 349 amino acids | | Primary Function | G protein-coupled receptor for galanin | | Expression | CNS (hippocampus, cortex, hypothalamus), peripheral nervous system | | Associated Diseases | AD, PD, epilepsy, depression, anxiety | </aside>
GALR1 — Galanin Receptor 1
Overview
GALR1 (Galanin Receptor 1) is a G protein-coupled receptor (GPCR) that binds the neuropeptide galanin. Located on chromosome 18q23, this gene encodes a 349-amino acid protein that is expressed primarily in the central nervous system, including the hippocampus, cortex, hypothalamus, and limbic system[@galr1_overview][@galr1_uniprot].
Galanin and its receptors, particularly GALR1, play important roles in modulating neurotransmitter systems, neuronal survival, neuroprotection, and various behavioral functions. Dysregulation of the galanin system has been implicated in Alzheimer's disease, Parkinson's disease, epilepsy, depression, and anxiety disorders, making GALR1 an attractive therapeutic target[@galanin_review2018][@galr1_neuroprotection2022].
| Property | Value | |---------|-------| | Gene Symbol | GALR1 | | Full Name | Galanin Receptor 1 | | Chromosome | 18q23 | | NCBI Gene ID | [25826](https://www.ncbi.nlm.nih.gov/gene/25826) | | Ensembl ID | ENSG00000134390 | | UniProt ID | [P47211](https://www.uniprot.org/uniprot/P47211) | | OMIM | 600041 | | Protein Length | 349 amino acids | | Primary Function | G protein-coupled receptor for galanin | | Expression | CNS (hippocampus, cortex, hypothalamus), peripheral nervous system | | Associated Diseases | AD, PD, epilepsy, depression, anxiety | </aside>
GALR1 — Galanin Receptor 1
Overview
GALR1 (Galanin Receptor 1) is a G protein-coupled receptor (GPCR) that binds the neuropeptide galanin. Located on chromosome 18q23, this gene encodes a 349-amino acid protein that is expressed primarily in the central nervous system, including the hippocampus, cortex, hypothalamus, and limbic system[@galr1_overview][@galr1_uniprot].
Galanin and its receptors, particularly GALR1, play important roles in modulating neurotransmitter systems, neuronal survival, neuroprotection, and various behavioral functions. Dysregulation of the galanin system has been implicated in Alzheimer's disease, Parkinson's disease, epilepsy, depression, and anxiety disorders, making GALR1 an attractive therapeutic target[@galanin_review2018][@galr1_neuroprotection2022].
Gene Structure and Protein Architecture
Gene Organization
The GALR1 gene spans approximately 35 kb and consists of 4 exons encoding a 349-amino acid GPCR protein with seven transmembrane domains. The gene is evolutionarily conserved across mammals.
Protein Structure
Mermaid diagram (expand to render)
N-terminal Extracellular Domain: Galanin binding site