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Alector

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slug	organizations-alector
entity_type	organization
kg_node_id	None

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Linked Artifacts (35)

related🧫Cytochrome Therapeutics70%

related🧫Cytochrome Therapeutics70%

mentions🧪APOE-TREM2 Interaction Modulation65%

mentions🧪Glycosaminoglycan Template Disruption Approach65%

mentions🧪TREM2-mediated microglial tau clearance enhancement65%

mentions🧪Ephrin-B2/EphB4 Axis Manipulation65%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination60%

related🧪APOE-TREM2 Interaction Modulation58%

related🧪Glycosaminoglycan Template Disruption Approach58%

related🧪TREM2-mediated microglial tau clearance enhancement58%

related🧪Ephrin-B2/EphB4 Axis Manipulation58%

related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination54%

mentions🧫Microglial TREM2 Agonist In Vivo Efficacy50%

mentions🧫TREM2 Agonist Therapy for Parkinson's Disease — Experim50%

mentions🧫TREM2 Function in Alzheimer's Disease — From Risk Varia50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE Isoform Conversion Therapy50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🧪APOE-TREM2 Interaction Modulation50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬What are the mechanisms underlying mechanistic role of apoe 50%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp39%