🧫
Analysis of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in cancer progression
active
experiment
Created: 2026-04-10T14:38:54
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-291a1cad-3f58-40eb-95c1-042d21a8077b
🧫 Experiment Protocol
Exploratoryesophageal squamous-cell carcinomaTP53, TP63, EFNB1, EPHB4human ESCC tissue samples and mouse modelsproposed
Pathological analysis was performed to investigate the TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in epithelial cancer formation and progression. The study examined how TP53 mutations lead to overexpression of ΔNP63, which in turn causes aberrant EFNB1-EPHB4 interactions. The analysis traced the progression from early precancerous lesions in the basal epithelial layer to whole epithelial layer involvement and strengthening interactions during cancer development. This work provided mechanistic insights into how TP53 mutations, a known culprit in human ESCC tumorigenesis, initiate a cascade of molecular events leading to EMT and enhanced proliferation.
PRIMARY OUTCOME
characterization of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis role in tumorigenesis
EXPECTED OUTCOMES
demonstration of mechanistic link between TP53 mutation and aberrant epithelial interactions
SUCCESS CRITERIA
evidence of TP53-TP63/ΔNP63 axis driving EFNB1-EPHB4 mediated EMT and proliferation
PROTOCOL
histopathological analysis and molecular characterization of cancer progression stages
LINKED HYPOTHESES
Source: PMID 38097539 ↗
🧫 Experiment Extras
PATHWAY
TP53-TP63/ΔNP63-EFNB1-EPHB4 signaling axis, EMT pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.