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Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early reduction of Somatostatin-expressing neuronal subtypes and late decreases in supragranular intratelenc
active
experiment
Created: 2026-04-27T23:14:42
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-5b95208cae8c
🧫 Experiment Protocol
Cell BiologyAlzheimer's diseasehumanextracted
Image-based quantitative neuropathology used to create continuous disease pseudoprogression score; single nuclei multiomic profiling with transcriptome and epigenome measurement; spatial transcriptomics; BRAIN Initiative Cell Census Network methodology; publicly available resource at SEA-AD.org
PRIMARY OUTCOME
Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early reduction of Somatostatin-expressing neuronal subtypes and late decreases in supragranular intratelencephalic-projecting excitatory and Parvalbumin-expressing neurons, with increases in disease-associated microglial and astrocytic states.
LINKED HYPOTHESES
Source: pmid_37292694
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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