🧫
Constitutive TUG cleavage mouse model
active
experiment
Created: 2026-04-06T12:32:55
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-73a8b41b-900a-431f-a97f-514565a43780
🧫 Experiment Protocol
Validationmetabolic regulationAspscr1/TUGmuscle-specific constitutive TUG cleavage miceproposed
Development and characterization of mice with muscle-specific constitutive TUG cleavage to study the downstream effects of TUG processing. This model allows continuous production of TUG C-terminal cleavage products independent of insulin stimulation. Researchers examined how constitutive TUG cleavage affects gene expression, particularly genes involved in lipid oxidation and thermogenesis, and measured effects on energy expenditure and metabolic function.
PRIMARY OUTCOME
gene expression changes and energy expenditure
EXPECTED OUTCOMES
Enhanced expression of thermogenic genes like sarcolipin and UCP1, increased energy expenditure
SUCCESS CRITERIA
Increased expression of target genes and measurable changes in metabolic parameters
PROTOCOL
Transgenic mouse generation, gene expression analysis, metabolic measurements, nuclear localization studies
Source: PMID 33686286 ↗
🧫 Experiment Extras
PATHWAY
PPARγ/PGC-1α transcriptional pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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