🧫
High fiber diet effects on gut microbiome and neuroinflammation in aging
active
experiment
Created: 2026-04-10T23:12:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-981d6333-ef1b-486a-b6dd-19d90113738f
🧫 Experiment Protocol
Validationage-related neuroinflammation and gut dysbiosisadult and aged miceproposed
This comprehensive study examined the effects of dietary fiber supplementation on gut microbiome composition, short-chain fatty acid production, intestinal inflammation, and microglial gene expression in adult and aged mice. Mice were fed either a low fiber diet (1% cellulose) or high fiber diet (5% inulin) for 4 weeks. The study measured gut microbiome alterations, SCFA production (butyrate, acetate, and total SCFAs), histological inflammation scoring in the distal colon, and gene expression analysis of inflammatory markers, epigenetic regulators, and microglial sensory apparatus (sensome) in the brain. Results showed that high fiber diet altered gut microbiome, increased SCFA production, reduced colonic inflammation in aged animals, and promoted a more anti-inflammatory microglial profile in aged mice.
PRIMARY OUTCOME
microglial gene expression profile and inflammatory status
EXPECTED OUTCOMES
High fiber diet would increase beneficial gut bacteria, increase SCFA production, reduce intestinal inflammation, and promote anti-inflammatory microglial phenotype
SUCCESS CRITERIA
Significant changes in gut microbiome composition, increased SCFA levels, reduced colonic inflammation scores, and altered microglial gene expression toward anti-inflammatory profile
PROTOCOL
4-week dietary intervention with either 1% cellulose (low fiber) or 5% inulin (high fiber) diet, followed by gut microbiome analysis, SCFA measurement, histological assessment of colon inflammation, and brain gene expression analysis
Source: PMID 30154787 ↗
🧫 Experiment Extras
PATHWAY
gut-brain axis, neuroinflammation, microglial activation, SCFA metabolism
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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