🧫
Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden across cortex and striatum compared to cognitively normal controls, while tau PET binding did not significantly differ between groups.
active
experiment
Created: 2026-04-27T23:43:11
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-a20c24c5d6d1
🧫 Experiment Protocol
NeuropathologyAlzheimer's diseaseAPP, PSEN1, or PSEN2 (ADAD mutations)in_vivoextracted
11C-PIB PET evaluated Aβ deposition; 18F-MK6240 PET assessed tau aggregation; participants categorized into Group 1 and Group 2 based on 18F-MK6240 uptake patterns
PRIMARY OUTCOME
Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden across cortex and striatum compared to cognitively normal controls, while tau PET binding did not significantly differ between groups.
LINKED HYPOTHESES
Source: pmid_39962560
🧫 Experiment Extras
PATHWAY
Aβ and tau pathology
MARKET PRICE
$0.50
STATUS
extracted
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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