🧫
In vitro screening for senolytic compounds
active
experiment
Created: 2026-04-10T14:44:27
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-acd97588-12e6-40d0-a242-ffc03e73c445
🧫 Experiment Protocol
Exploratorycellular senescencesenescent cells in cultureproposed
A compound screening was performed to identify drugs that could selectively kill senescent cells. The researchers tested a collection of compounds on senescent cells in culture and identified ABT263 (a specific inhibitor of anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. The screening evaluated the ability of compounds to selectively induce apoptosis in senescent cells compared to non-senescent cells across different cell types and species.
PRIMARY OUTCOME
selective killing of senescent cells
EXPECTED OUTCOMES
Identification of compounds that selectively kill senescent cells without affecting normal cells
SUCCESS CRITERIA
Selective cytotoxicity against senescent cells with minimal effect on non-senescent cells
PROTOCOL
Compound screening on senescent cells in culture, assessment of cell viability and apoptosis induction
Source: PMID 26657143 ↗
🧫 Experiment Extras
PATHWAY
BCL-2/BCL-xL apoptosis pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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