🧫
Single-nucleus RNA-seq integration analysis
active
experiment
Created: 2026-04-11T00:50:30
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-bf864e40-c3cf-4450-94ad-9ed37bb0456d
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseDACT1, DAAM1, KCNJ3, KLHDC4, SLC10A7, PPP4R2postmortem human brain tissue - Korean ancestryproposed
Integration of GWAS results with ancestry-matched Korean single-nucleus RNA sequencing data from postmortem brain tissue to provide cell type-specific functional annotations of identified genetic loci. This analysis aimed to link genetic variants to gene expression patterns in specific brain cell types, particularly focusing on oligodendrocytes where DACT1 was implicated as a key regulatory mediator of pTau217. The integration also included differential gene expression data from the ROSMAP cohort to further validate findings.
PRIMARY OUTCOME
cell type-specific gene expression patterns
EXPECTED OUTCOMES
Cell type-specific annotation of GWAS loci, identification of regulatory mechanisms in relevant brain cell types
SUCCESS CRITERIA
significant association between genetic variants and cell type-specific gene expression
PROTOCOL
Single-nucleus RNA sequencing, integration with GWAS results, cell type annotation, differential expression analysis
LINKED HYPOTHESES
Source: PMID 41804841 ↗
🧫 Experiment Extras
PATHWAY
cell type-specific gene regulation, oligodendrocyte function
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Outgoing
0
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0 contradicting
0 neutral
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