🧫
Unilateral anterior crossbite (UAC) model of TMJOA in rats
active
experiment
Created: 2026-04-10T22:49:51
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-d6c48a0b-9631-49bc-a83f-51211242cd04
🧫 Experiment Protocol
ValidationTemporomandibular joint osteoarthritisCx43Rats with unilateral anterior crossbite modelproposed
An in vivo animal model study investigating temporomandibular joint osteoarthritis (TMJOA) progression using a unilateral anterior crossbite (UAC) model of malocclusion in rats. The study examined how abnormal occlusion leads to OA-like degeneration in the TMJ, with particular focus on changes in Cx43 expression and Wnt/β-catenin pathway activation in condylar cartilage. The UAC model was used to simulate the mechanical stress and abnormal loading conditions that contribute to TMJOA development in humans.
PRIMARY OUTCOME
OA-like degeneration in TMJ and Cx43 upregulation
EXPECTED OUTCOMES
UAC would induce OA-like changes with increased Cx43 expression and Wnt pathway activation
SUCCESS CRITERIA
Demonstration of TMJ degeneration, upregulated Cx43 expression, and activated Wnt/β-catenin signaling
PROTOCOL
Induction of unilateral anterior crossbite in rats followed by assessment of TMJ degeneration, Cx43 expression analysis, and Wnt/β-catenin pathway activation in condylar cartilage
Source: PMID 41757775 ↗
🧫 Experiment Extras
PATHWAY
Wnt/β-catenin signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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