🧫
PPARγ2 Pro12Ala polymorphism analysis
active
experiment
Created: 2026-04-06T12:32:55
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-e47738bc-f141-41f2-a1a4-06298fd5e030
🧫 Experiment Protocol
ExploratorydiabetesPPARγ2human genetic variant analysisproposed
Analysis of the PPARγ2 Pro12Ala polymorphism, which is known to reduce diabetes risk, and its relationship to TUG binding. The study examined how this specific amino acid change affects the interaction between TUG cleavage products and PPARγ2. Researchers investigated whether the protective Pro12Ala variant enhances TUG binding compared to the wild-type sequence, potentially explaining part of its protective effect against diabetes through enhanced insulin sensitivity and metabolic function.
PRIMARY OUTCOME
TUG binding affinity to PPARγ2 variants
EXPECTED OUTCOMES
Enhanced TUG binding to Pro12Ala variant compared to wild-type PPARγ2
SUCCESS CRITERIA
Measurably increased binding affinity for the protective polymorphic variant
PROTOCOL
Protein binding assays, functional studies with variant proteins, interaction measurements
Source: PMID 33686286 ↗
🧫 Experiment Extras
PATHWAY
PPARγ signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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