🧫
Microglial depletion rescue experiment
active
experiment
Created: 2026-04-06T12:28:17
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-ebdf4d9c-599e-48ac-97db-101691f675e4
🧫 Experiment Protocol
Validationperioperative neurocognitive disordersratsproposed
This intervention experiment involved depleting microglia in the sevoflurane-induced neurotoxicity model to test whether microglial activation was necessary for the observed pathological changes. The study aimed to determine if removing microglia could prevent or reverse the neuroinflammation, complement activation, synaptic loss, cognitive dysfunction, and anxiety-like behaviors induced by prolonged anesthesia. The results showed that microglial depletion ameliorated neuroinflammation activation, reduced complement system activation, rescued synaptic loss, and improved both cognitive dysfunction and anxiety-like behaviors. This experiment provided crucial evidence that microglia play a central role in the pathological cascade triggered by prolonged anesthesia.
PRIMARY OUTCOME
rescue of cognitive dysfunction and anxiety-like behaviors
EXPECTED OUTCOMES
Prevention of neuroinflammation, complement activation, synaptic loss, and behavioral deficits
SUCCESS CRITERIA
Amelioration of neuroinflammation, complement activation, synaptic preservation, and behavioral improvement
PROTOCOL
Microglial depletion followed by prolonged sevoflurane anesthesia and assessment of neuroinflammation, complement activation, synaptic integrity, and behavioral outcomes
Source: PMID 36600274 ↗
🧫 Experiment Extras
PATHWAY
microglial activation pathway, neuroinflammation, complement cascade
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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