🧫
rTMS for preventing chronic postsurgical pain in thoracoscopic surgery
active
experiment
Created: 2026-04-10T22:45:38
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-f6960c90-cabb-4c30-ad73-d394ca8e3206
🧫 Experiment Protocol
Clinicalchronic postsurgical painhuman patients undergoing thoracoscopic lung cancer surgeryproposed
This randomized controlled trial investigated whether early postoperative repetitive transcranial magnetic stimulation (rTMS) could reduce chronic postsurgical pain (CPSP) in older patients undergoing thoracoscopic lung cancer surgery. The study targeted the left dorsolateral prefrontal cortex with high-frequency rTMS (10 Hz, 100% resting motor threshold, 2000 pulses per session) administered immediately after extubation in the post-anesthesia care unit. The trial followed 198 patients for 3 months to assess clinical outcomes including CPSP incidence, anxiety, depression scores, and inflammatory biomarkers. The intervention aimed to prevent the development of chronic pain through neuromodulation of pain processing circuits in the brain.
PRIMARY OUTCOME
incidence of chronic postsurgical pain at 3 months
EXPECTED OUTCOMES
Reduction in CPSP incidence, improved anxiety and depression scores, decreased inflammatory biomarkers
SUCCESS CRITERIA
Significant reduction in CPSP incidence compared to sham group
PROTOCOL
Randomized controlled trial with 286 patients screened, 230 randomized to active or sham rTMS targeting left DLPFC (10 Hz, 100% RMT, 2000 pulses) immediately post-extubation. 3-month follow-up with blinded evaluators assessing clinical and biochemical outcomes.
Source: PMID 41943114 ↗
🧫 Experiment Extras
PATHWAY
pain processing, dorsolateral prefrontal cortex modulation, inflammatory pathways
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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