🧫
PDGFRA and C-MYC protein validation in ovarian cancer tissues
active
experiment
Created: 2026-04-10T22:35:41
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-f7bde0cc-8c06-4e9b-a146-bb381b9c224d
🧫 Experiment Protocol
ExploratoryOvarian cancerPDGFRA, C-MYCHuman ovarian cancer tissuesproposed
This experimental validation study focused on confirming the upregulation and interaction of PDGFRA and C-MYC proteins in ovarian cancer tissues. The researchers performed Western blot analysis to validate the upregulation of both PDGFRA and C-MYC proteins in ovarian cancer tissues compared to normal tissues. Additionally, they conducted co-localization and immunofluorescence analyses to examine the spatial relationship and expression patterns of these proteins within the tissue samples. PDGFRA was identified as a key model gene with predictive performance for ovarian cancer prognosis. This validation provided experimental evidence supporting the bioinformatics findings regarding the importance of PDGFRA in ovarian cancer progression and prognosis.
PRIMARY OUTCOME
Protein expression validation and co-localization
EXPECTED OUTCOMES
Upregulation of PDGFRA and C-MYC in ovarian cancer tissues, co-localization of proteins
SUCCESS CRITERIA
Significant upregulation compared to normal tissues, clear co-localization signals
PROTOCOL
Western blot analysis, immunofluorescence microscopy, co-localization analysis
LINKED HYPOTHESES
Source: PMID 41946148 ↗
🧫 Experiment Extras
PATHWAY
PDGF signaling pathway, MYC signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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