Blood-Brain Barrier Pericyte-to-Mesenchymal Transition Drives Vascular Collapse
🧪 Overview
Pericyte-to-fibroblast transition contributes to BBB breakdown and impairs glymphatic clearance. Chronic PDGFRβ signaling triggers pericytes to undergo partial endothelial-mesenchymal transition. These transition-state pericytes lose coverage but gain contractile apparatus, compressing capillaries and reducing cerebral blood flow while impairing AQP4 polarisation necessary for glymphatic clearance.
🧬 Mechanism
⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — PDGFRΒ
No curated PDB or AlphaFold mapping for PDGFRΒ yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for PDGFRβ, SNAI2.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
▸Metadataorigin_type: debate_synthesizer
| origin_type | debate_synthesizer |
| target_gene | PDGFRβ, SNAI2/SLUG, AQP4 |
| _schema_version | 1 |
| composite_score | 0.56 |