Tau propagation through muscarinic receptor-mediated BBB transcytosis
🧪 Overview
The hypothesis proposes that pathological tau enters or spreads through the CNS via M1/M3 muscarinic receptor-mediated BBB transcytosis, with LRP1 and other uptake pathways contributing. This is the least development-ready program because LRP1-mediated tau uptake is credible but the muscarinic BBB mechanism remains speculative and experimentally under-tested.
🧬 Mechanism
⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — CHRM1;
No curated PDB or AlphaFold mapping for CHRM1; yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for CHRM1; CHRM3; LRP1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesizer
| source | v1_phase_c_backfill |
| origin_type | debate_synthesizer |
| _schema_version | 1 |