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Role of ApoE in conformation-prone diseases and atherosclerosis.
active
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Created:
By: unknown
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50%
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ID: paper-16903824
📄 Paper Details
Role of ApoE in conformation-prone diseases and atherosclerosis.
["Dergunov A"]
Abstract
Three isoforms of human plasma apolipoprotein E (apoE) are ligands to lipoprotein receptors and influence in different manner the synthesis and catabolism of pro-atherogenic triglyceride-rich lipoproteins. Among three isoforms, the apoE4 isoform is associated with increased frequency of atherosclerosis and Alzheimer's disease (AD). The conformational transitions of beta-amyloid (Abeta) influenced by apoE and serum amyloid P (SAP) component are key events in AD development, the accumulation of in...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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Outgoing
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