📄
Schizophrenia risk from complex variation of complement component 4.
active
📄 Paper Details
Schizophrenia risk from complex variation of complement component 4.
["Sekar A", "Bialas AR", "de Rivera H", "Davis A", "Hammond TR", "Kamitaki N", "Tooley K", "Presumey J", "Baum M", "Van Doren V", "Genovese G", "Rose SA", "Handsaker RE", "Daly MJ", "Carroll MC", "Ste
Abstract
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying lev...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.