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Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.
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ID: paper-28724645
📄 Paper Details
Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.
["Valera-Gran D", "Navarrete-Mu\u00f1oz E", "Garcia de la Hera M", "Fern\u00e1ndez-Somoano A", "Tard\u00f3n A", "Ibarluzea J", "Balluerka N", "Murcia M", "Gonz\u00e1lez-Safont L", "Romaguera D"]
Abstract
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 μg/d) on child neurocognitive outcomes.Objective: The objective of the study was to examine the association between the use of high dosages of ...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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