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Thyroid Hormone Transporters.
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ID: paper-31754699
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Thyroid Hormone Transporters.
["Groeneweg S", "van Geest F", "Peeters R", "Heuer H", "Visser W"]
Abstract
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in ...
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