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Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A.
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ID: paper-33533918
📄 Paper Details
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A.
["Nikolakopoulou A", "Wang Y", "Ma Q", "Sagare A", "Montagne A", "Huuskonen M", "Rege S", "Kisler K", "Dai Z", "K\u00f6rbelin J"]
Abstract
The low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic and cell signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood-brain barrier (BBB), regulates angiogenesis, and is increasingly reduced in Alzheimer's disease associated with BBB breakdown and neurodegeneration. Whether loss of endothelial LRP1 plays a direct causative role in BBB breakdown and neurodegenerative changes remains elusive. Here, we show that LRP1 inactivation from the ...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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Outgoing
1
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