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Sleep-improving effect and the potential mechanism of Morus alba L. on mice.
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ID: paper-39255910
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Sleep-improving effect and the potential mechanism of Morus alba L. on mice.
Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu J, Lu J
Abstract
As insufficient sleep has become a widespread concern in modern society, potential sleep-improving effect of mulberry (Morus alba L.) leaf ethanol extract (MLE) and the related mechanism were investigated in the present study. According to the results, MLE could significantly shorten sleep latency by 33 %, extend sleep duration by 56 % and increase sleep ratio of mice through increasing 5-HT and GABA release in serum, hypothalamus and hippocampus. Metabonomic analysis showed that phenylalanine m...
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